Tissue-Engineered Implants for Cardio-Vascular Surgery, Traumatology and Orthopedics

Tissue-engineering implants based on biomaterials are widely used for reconstructive cardiovascular surgery, traumatology, orthopedics, maxillofacial surgery. Some modification of these materials is required to provide regenerative and reconstructive properties taking into account understanding the mechanisms of body reaction against implanted materials, mechanisms of tissue regeneration stimulated by implants.

In the laboratory of tissue engineering at ITEB RAS the mechanisms of calcification of biomaterials for cardiovascular surgery are studied and new technologies are developed for suppressing the pathological calcification of these biomaterials, to improve their functionality. Some of these technologies were introduced into the process of heart valve allograft modification in Bakulev Center of Cardiovascular Surgery.

Laboratory of Tissue Engineering at ITEB RAS develops also new biomaterials for traumatology and orthopedics, and studies effects of these biomaterials on the regeneration of bone, tendons and ligaments in laboratory animals. These biomaterials are developed in cooperation with Moscow centers of traumatology and orthopedics.